Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Definitions and criteria for stem cells.

Leslie P Weiner1

  • 1Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|March 29, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Repopulation of T, B, and NK cells following alemtuzumab treatment in relapsing-remitting multiple sclerosis.

Journal of neuroinflammation·2020
Same author

Smek1/2 is a nuclear chaperone and cofactor for cleaved Wnt receptor Ryk, regulating cortical neurogenesis.

Proceedings of the National Academy of Sciences of the United States of America·2017
Same author

The influence of retinoic acid on the human oligodendrocyte precursor cells by RNA-sequencing.

Biochemistry and biophysics reports·2017
Same author

Effects of dimethyl fumarate on lymphocyte subsets.

Multiple sclerosis and related disorders·2015
Same author

In vitro assessment of the direct effect of laquinimod on basic functions of human neural stem cells and oligodendrocyte progenitor cells.

Journal of the neurological sciences·2014
Same author

Assessment of changes in immune measures of multiple sclerosis patients treated with laquinimod.

Journal of neuroimmunology·2013
Same journal

Tracking Synthetic Adhesins on Bacterial Surfaces with Immunofluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Post-Selection Methods for Analyzing mRNA Display Selections and Optimization of Hits.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

High-Performance Computing in Tandem Mass Spectrometry (MS/MS) Peptide Identification.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Engineering and Adapting Disulfide-Containing Proteins to Enable Intracellular Functionality.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

AI-Driven Protein Research: From Prediction to Design.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for the In Vitro Selection of Protein and Peptide Libraries Using mRNA Display.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Neural stem cells (NSCs) hold promise for treating central nervous system (CNS) diseases due to their self-renewal and differentiation capabilities. Further research is needed to understand their complexity and ensure safe clinical application.

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Developmental Biology

Background:

  • Stem cells are defined by self-renewal and differentiation potential.
  • Neural stem cells (NSCs) originate from neuroepithelial cells in the central nervous system (CNS).
  • Adult NSCs and progenitors persist in the CNS throughout life.

Purpose of the Study:

  • To explore the potential of human embryonic stem cells as a source for NSCs.
  • To highlight the need for further research into NSC complexity and CNS microenvironments.
  • To identify requirements for safe clinical application of NSCs.

Main Methods:

  • Review of stem cell definitions and origins.
  • Discussion of NSC development from embryonic ectoderm.
  • Analysis of potential therapeutic applications and challenges.

Related Experiment Videos

Main Results:

  • Human embryonic stem cells exhibit properties suitable for generating NSCs.
  • NSCs are complex and require specific microenvironments for CNS integration.
  • Challenges include defining cell populations, avoiding oncogenicity, and ensuring survival.

Conclusions:

  • Human embryonic stem cells represent a promising source for neural stem cells.
  • Extensive research is crucial to characterize NSCs and their microenvironment for therapeutic use.
  • Clarifying production methods, safety, and survival is essential before clinical application.