Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cloning of Dolly the Sheep01:08

Cloning of Dolly the Sheep

The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter telomeres than other...
Reproductive Cloning01:27

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...
Reproductive Cloning01:27

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...
Parental Care00:55

Parental Care

Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
Asexual Reproduction02:38

Asexual Reproduction

Asexual reproduction allows plants to reproduce without growing flowers, attracting pollinators, or dispersing seeds. Offspring are genetically identical to the parent and produced without the fusion of male and female gametes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effects of Developmental Ethanol Exposure & Postnatal Choline Supplementation on Long-Term Choline Metabolism.

Alcohol (Fayetteville, N.Y.)·2026
Same author

Prenatal cannabidiol exposure alters physical and behavioral development in rats.

Neurotoxicology and teratology·2026
Same author

Evaluation of Choline Metabolic Genes in the Liver of the Dam as Candidates for Mediating Choline's Efficacy in Mitigating Ethanol-Induced Cell Death in the Neural Tube: A Preliminary Analysis.

Genes·2026
Same author

Postnatal choline supplementation improves sleep in a rat model of developmental alcohol exposure.

Alcohol, clinical & experimental research·2025
Same author

Control of precision grip in children with heavy prenatal alcohol exposure.

Alcohol, clinical & experimental research·2024
Same author

Altered circadian expression of clock genes and clock-regulatory epigenetic modifiers in saliva of children with fetal alcohol spectrum disorders.

Scientific reports·2024

Related Experiment Video

Updated: Jul 6, 2026

Rearing and Long-Term Maintenance of Eristalis tenax Hoverflies for Research Studies
10:50

Rearing and Long-Term Maintenance of Eristalis tenax Hoverflies for Research Studies

Published on: May 19, 2018

Artificial rearing.

Hector D Dominguez1, Jennifer D Thomas

  • 1Center for Behavioral Teratology, Department of Psychology, San Diego State University, San Diego, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|March 29, 2008
PubMed
Summary
This summary is machine-generated.

Artificial rearing in rats models prenatal alcohol exposure effects on brain development. This method allows researchers to study fetal alcohol spectrum disorders (FASD) by delivering alcohol to neonatal pups during critical developmental periods.

More Related Videos

Hand-Rearing Method for Infant Marmosets
04:52

Hand-Rearing Method for Infant Marmosets

Published on: June 9, 2023

Basic Methods for the Study of Reproductive Ecology of Fish in Aquaria
07:25

Basic Methods for the Study of Reproductive Ecology of Fish in Aquaria

Published on: July 20, 2017

Related Experiment Videos

Last Updated: Jul 6, 2026

Rearing and Long-Term Maintenance of Eristalis tenax Hoverflies for Research Studies
10:50

Rearing and Long-Term Maintenance of Eristalis tenax Hoverflies for Research Studies

Published on: May 19, 2018

Hand-Rearing Method for Infant Marmosets
04:52

Hand-Rearing Method for Infant Marmosets

Published on: June 9, 2023

Basic Methods for the Study of Reproductive Ecology of Fish in Aquaria
07:25

Basic Methods for the Study of Reproductive Ecology of Fish in Aquaria

Published on: July 20, 2017

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Toxicology

Background:

  • Prenatal alcohol exposure causes fetal alcohol spectrum disorders (FASD), impacting physical, neurological, and behavioral development.
  • Animal models are crucial for understanding FASD mechanisms, risk factors, and potential interventions.
  • Rodent brain development differs from humans; modeling third-trimester equivalent alcohol exposure requires postnatal manipulation.

Purpose of the Study:

  • To describe the artificial rearing technique for exposing neonatal rats to alcohol.
  • To provide methods for modeling third-trimester equivalent alcohol exposure in rats.
  • To facilitate research on fetal alcohol spectrum disorders (FASD) using a rodent model.

Main Methods:

  • Artificial rearing involves housing neonatal rat pups in a controlled environment.
  • Automated intragastric feeding delivers a milk substitute to ensure adequate growth.
  • Alcohol is administered via the milk diet during early postnatal development (postnatal days 4-9).
  • Key procedural steps include preparing the rearing environment and performing gastrostomy surgery.

Main Results:

  • This method enables controlled alcohol administration during a critical window of rat brain development.
  • Artificial rearing supports adequate growth in neonatal pups during the exposure period.
  • The described techniques allow for consistent and reproducible alcohol delivery.

Conclusions:

  • Artificial rearing is a viable method for modeling prenatal alcohol exposure and its effects on brain development in rats.
  • This technique is essential for studying the neurodevelopmental consequences of fetal alcohol spectrum disorders (FASD).
  • Detailed methodological descriptions aid researchers in applying this model system effectively.