Extended-release oral drug delivery technologies: monolithic matrix systems
Sandip B Tiwari1, Ali R Rajabi-Siahboomi
1Modified Release Technologies, Colorcon, West Point, PA, USA.
Methods in Molecular Biology (Clifton, N.J.)
|March 29, 2008
Summary
Hydrophilic matrices are key for oral extended-release drug delivery. This review covers polymer selection and formulation factors influencing the performance of these extended-release products.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Oral drug delivery dominates the pharmaceutical market due to its convenience and patient preference.
- Hydrophilic matrices are a widely adopted technology for achieving oral extended drug release.
Purpose of the Study:
- To review polymer selection for monolithic hydrophilic matrices.
- To discuss formulation and manufacturing variables impacting extended-release product performance.
Main Methods:
- Literature review of polymer choices for hydrophilic matrices.
- Analysis of formulation and manufacturing parameters through practical examples.
Main Results:
- Identified various polymer options suitable for hydrophilic matrix fabrication.
- Detailed the influence of critical formulation and manufacturing variables on drug release profiles.
Conclusions:
- Optimizing polymer choice and controlling formulation/manufacturing processes are essential for successful extended-release hydrophilic matrix development.
- This chapter provides a comprehensive guide for designing effective extended-release oral drug delivery systems.
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