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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: Jul 6, 2026

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

Gene delivery to mesenchymal stem cells.

Reza Izadpanah¹, Bruce A Bunnell

¹Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA, USA.

Methods in Molecular Biology (Clifton, N.J.)

|March 29, 2008

Summary

Gene therapy requires effective delivery to target cells. Mesenchymal stem cells (MSCs) are ideal for gene delivery due to their differentiation potential and ability to maintain transgene expression for tissue engineering applications.

Area of Science:

Biotechnology
Cell Biology
Regenerative Medicine

Background:

Gene therapy success hinges on efficient delivery to target cells.
Mesenchymal stem cells (MSCs) are promising for tissue engineering due to their differentiation capabilities.
Autologous stem cell-based delivery offers a targeted therapeutic strategy.

Purpose of the Study:

To describe methods for gene delivery to mesenchymal stem cells (MSCs).
To highlight MSCs as valuable targets for gene therapy and tissue engineering.

Main Methods:

Transduction of MSCs with integrating vectors.
Utilizing MSCs' high amphotropic receptor levels for efficient gene uptake.
Maintaining transgene expression in vitro and in vivo.

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Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

Related Experiment Videos

Last Updated: Jul 6, 2026

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

Main Results:

MSCs are readily transduced with integrating vectors.
Transgene expression is maintained in MSCs without affecting multipotentiality.
MSCs demonstrate potential for cell-based gene delivery.

Conclusions:

Mesenchymal stem cells are highly suitable targets for gene therapy.
The described methods facilitate gene delivery to MSCs for therapeutic applications.
MSCs are poised to be crucial cytoreagents in future gene therapy strategies.