Related Experiment Video
Updated: Jul 6, 2026
Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
Published on: December 8, 2023
Hematopoietic stem cell transplant in mice by intra-femoral injection
1Gene Therapy Laboratories, Norris Cancer Center, University of Southern California School of Medicine, Los Angeles, CA, USA.
In traditional bone marrow transplantation, the majority of peripherally introduced stem cells are trapped in peripheral organs, such as the lung and liver. The frequency of cells homed in bone marrow by such method is extremely low. This circumstance adds difficulty to the research of hematopoietic stem cell (HSC), a rare population to begin with. By introducing HSC directly into bone marrow cavity, the peripheral loss of HSC can be minimized. Thus, intra-femoral injection of HSC is a useful method for HSC study.
In traditional bone marrow transplantation, the majority of peripherally introduced stem cells are trapped in peripheral organs, such as the lung and liver. The frequency of cells homed in bone marrow by such method is extremely low. This circumstance adds difficulty to the research of hematopoietic stem cell (HSC), a rare population to begin with. By introducing HSC directly into bone marrow cavity, the peripheral loss of HSC can be minimized. Thus, intra-femoral injection of HSC is a useful method for HSC study.
