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[Tumor search with diffusion-weighted imaging--first experience].

A Bohlscheid1, D Nuss, S Lieser

  • 1Zentrum für Radiologie, Sonografie und Nuklearmedizin, Krankenhaus der Barmherzigen Brüder Trier, Nordallee 1, Trier. bohlscheid@gmx.net

Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|March 29, 2008
PubMed
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Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) is a fast and robust MRI technique for detecting tumors. While generally sensitive, its specificity can be limited in certain cases, requiring careful interpretation.

Area of Science:

  • Oncological Imaging
  • Radiology
  • Medical Physics

Background:

  • Diffusion-weighted imaging (DWI) offers a novel parameter for oncological assessment.
  • Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) is a specialized MRI sequence.

Purpose of the Study:

  • To evaluate DWIBS as a tool for tumor detection in primary oncological staging.
  • To assess the utility of DWIBS in monitoring patients after cancer treatment.

Main Methods:

  • The DWIBS sequence was implemented in oncological MRI protocols.
  • Whole-body and organ-specific scans were performed on volunteers and cancer patients.
  • Neoplastic lesions identified on conventional MRI were analyzed for visibility and signal intensity on DWIBS.

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Main Results:

  • 113 of 125 DWIBS examinations were technically successful.
  • Malignant lesions showed a bright signal in 58 of 64 patients; 6 showed moderate or no signal.
  • DWIBS visualized lesions close to voxel size and demonstrated signal changes correlating with treatment response or recurrence.

Conclusions:

  • DWIBS is a fast, robust technique providing an independent parameter in oncological scanning.
  • Maximum intensity projections aid in visualizing disease spread.
  • DWIBS shows high sensitivity for lymphomas and gastrointestinal tumors but limited specificity for certain lesions.