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Updated: Jul 6, 2026
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Temsirolimus: in advanced renal cell carcinoma
Dene Simpson1, Monique P Curran
1Wolters Kluwer Health, Adis, Auckland, New Zealand. demail@adis.co.nz
Drugs
|March 29, 2008
Summary
Temsirolimus significantly improved survival for advanced renal cell carcinoma patients compared to interferon-alpha. This mTOR inhibitor demonstrated better progression-free survival and fewer adverse events.
Area of Science:
- Oncology
- Pharmacology
- Molecular Biology
Background:
- Advanced renal cell carcinoma (RCC) presents a poor prognosis.
- Current therapies like interferon-alpha (IFNalpha) have limitations.
- Targeting the mammalian target of rapamycin (mTOR) pathway is a therapeutic strategy.
Purpose of the Study:
- To evaluate the efficacy and safety of temsirolimus in patients with advanced RCC.
- To compare temsirolimus monotherapy against standard IFNalpha treatment.
Main Methods:
- A large phase III clinical study was conducted.
- Patients received either a once-weekly intravenous infusion of temsirolimus (25 mg) or subcutaneous IFNalpha (3-18 MU three times weekly).
- Survival outcomes, objective response rates, and adverse events were assessed.
Main Results:
- Temsirolimus showed significant survival benefits: median overall survival of 10.9 months vs. 7.3 months for IFNalpha.
- Progression-free survival was notably improved with temsirolimus (5.5 months vs. 3.1 months).
- Objective response rates were higher for temsirolimus (8.6%) than IFNalpha (4.8%), with fewer severe adverse events.
Conclusions:
- Temsirolimus monotherapy offers significant survival advantages for advanced RCC patients with poor prognosis.
- Temsirolimus is a well-tolerated treatment option with a favorable safety profile compared to IFNalpha.
- Targeting the mTOR pathway with temsirolimus is an effective strategy in advanced renal cell carcinoma treatment.
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