Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blind Procedures02:07

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Evidence for Mixing-Induced CP Violation in B_{s}^{0}→J/ψϕ(1020) Decays in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

Measurement of D^{0} Meson Photoproduction in Ultraperipheral Heavy Ion Collisions.

Physical review letters·2026
Same author

Observation of Coherent ϕ(1020) Meson Photoproduction in Ultraperipheral PbPb Collisions at sqrt[s_{NN}]=5.36  TeV.

Physical review letters·2026
Same author

Search for New Physics in Jet Multiplicity Patterns of Multilepton Events at sqrt[s]=13  TeV.

Physical review letters·2025
Same author

Search for the Rare Decay D^{0}→μ^{+}μ^{-} in Proton-Proton Collisions at sqrt[s]=13.6  TeV.

Physical review letters·2025
Same author

Observation of Λ Hyperon Local Polarization in p-Pb Collisions at sqrt[s_{NN}]=8.16  TeV.

Physical review letters·2025
Same journal

Effectiveness of the Approved Nirmatrelvir/Ritonavir and Molnupiravir Regimens for Treatment of Mild/Moderate Laboratory-Confirmed SARS-CoV-2 Infection in Patients Aged 18-64 Years in Hong Kong: A Population-Based Cohort Study.

Clinical drug investigation·2026
Same journal

Assessing the Adverse Events of Roflumilast and Tapinarof Use in Pediatric and Young Adult Patients with Atopic Dermatitis: A Systematic Review.

Clinical drug investigation·2026
Same journal

Repurposing Antipsychotics in Cancer Therapy: Modulation of Autophagy Mechanisms.

Clinical drug investigation·2026
Same journal

Deuruxolitinib: New Approval.

Clinical drug investigation·2026
Same journal

Efficacy, Safety, Quality of Life, and Adherence of Dupilumab in Pediatric Atopic Dermatitis: A Systematic Review.

Clinical drug investigation·2026
Same journal

Optimizing Amiodarone Maintenance Dose to Minimize N-Desethylamiodarone Accumulation and Pulmonary Toxicity: Insights from Machine Learning and Pharmacokinetic Simulation.

Clinical drug investigation·2026
See all related articles

Related Experiment Video

Updated: Jul 6, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

: a prospective, randomised, double-blind, controlled multicentre study.

H Røgind1, H Bliddal, D Klokker

  • 1Department of Rheumatology, Copenhagen Municipal Hospital, Copenhagen, Denmark.

Clinical Drug Investigation
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

This study found etodolac and piroxicam equally effective for osteoarthritis pain relief. However, etodolac demonstrated a significantly lower incidence of adverse events compared to piroxicam.

More Related Videos

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial)
04:11

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial)

Published on: June 9, 2026

Related Experiment Videos

Last Updated: Jul 6, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial)
04:11

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial)

Published on: June 9, 2026

Area of Science:

  • Rheumatology
  • Pharmacology
  • Clinical Medicine

Background:

  • Osteoarthritis (OA) is a prevalent degenerative joint disease.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for OA symptom management.
  • Comparing the efficacy and safety of different NSAIDs is crucial for optimal patient care.

Purpose of the Study:

  • To compare the efficacy and safety of etodolac and piroxicam in patients with hip or knee osteoarthritis.
  • To specifically evaluate clinical gastrointestinal adverse effects associated with both NSAIDs.

Main Methods:

  • An 8-week prospective, multicentre, randomised, double-blind trial involving 271 OA patients.
  • Efficacy assessed via patient and investigator evaluations of key parameters at baseline, 4, and 8 weeks.
  • Tolerability evaluated through patient-reported adverse events and laboratory tests.

Main Results:

  • Both etodolac and piroxicam significantly improved patient and investigator assessments of OA symptoms.
  • No statistically significant differences in efficacy were observed between the two NSAIDs.
  • Etodolac (30%) showed a significantly lower overall adverse event rate than piroxicam (46%) (p < 0.01).
  • Gastrointestinal adverse events and haemoglobin changes did not significantly differ between groups.

Conclusions:

  • Etodolac 600mg daily is as effective as piroxicam 20mg daily for osteoarthritis treatment.
  • Etodolac is associated with a significantly better overall tolerability profile than piroxicam.
  • No significant difference in clinical gastrointestinal adverse events between etodolac and piroxicam.