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Related Experiment Video

Updated: Jul 6, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

A M Murad1, C A Andrade, C Delfino

  • 1Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Clinical Drug Investigation
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

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Uracil and tegafur (UFT) offers a cost-effective oral alternative to intravenous 5-fluorouracil (5-FU) for colorectal cancer treatment. This study found UFT to be economically favorable in Brazil and Argentina, especially for metastatic disease.

Area of Science:

  • Oncology
  • Pharmacoeconomics

Background:

  • Colorectal cancer treatment presents significant challenges globally.
  • Intravenous 5-fluorouracil (5-FU) based regimens are standard, but oral Uracil and tegafur (UFT) offers a patient-focused alternative.
  • UFT demonstrates comparable clinical outcomes to 5-FU with a milder toxicity profile, warranting economic evaluation.

Purpose of the Study:

  • To conduct a pharmacoeconomic analysis comparing oral UFT/leucovorin with intravenous 5-FU/levamisole and/or leucovorin in Brazil and Argentina.
  • To evaluate treatment costs from a healthcare payor perspective, considering clinical practices and adverse event management.

Main Methods:

  • A pharmacoeconomic model was developed using physician expert panels in Brazil and Argentina.
  • Resource utilization trends were assessed based on identified clinical practices and events.

Related Experiment Videos

Last Updated: Jul 6, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

  • Country-specific charge data were applied to calculate average costs per patient for a 6-cycle course of therapy.

    • Main Results:

    • In Brazil, UFT showed equivalent costs in the adjuvant setting and a cost saving of R$335/patient for metastatic disease compared to 5-FU.
    • In Argentina, UFT demonstrated cost savings of P782/patient (adjuvant) and P1188/patient (metastatic) over 5-FU.
    • Cost differences were primarily driven by UFT's mild toxicity and associated reduced adverse event management costs.

    Conclusions:

    • UFT is a therapeutically equivalent and economically advantageous alternative to 5-FU for colorectal cancer in Brazil and Argentina.
    • The oral formulation and favorable toxicity profile of UFT contribute to lower total healthcare costs and potentially improved patient quality of life.