Related Experiment Video
Updated: Jul 6, 2026

07:30
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
: prevalence and association with drug use.
C Cornelius1, J Fastbom, C B Claesson
1Stockholm Gerontology Research Centre & Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden.
Clinical Drug Investigation
|January 1, 1997
Summary
This study examined symptoms and medication use in elderly individuals. Pain and tiredness were common, with some drug use potentially indicating inappropriate treatment or dosage.
Area of Science:
- Gerontology
- Clinical Pharmacology
- Epidemiology
Background:
- Prevalence of self-reported symptoms and medication use is high in elderly populations.
- Understanding symptom-drug associations is crucial for optimizing geriatric pharmacotherapy.
- The Kungsholmen Project provides a robust dataset for studying health in older adults.
Purpose of the Study:
- To investigate the prevalence of self-reported symptoms in elderly individuals.
- To determine the association between these symptoms and medicinal drug use.
- To identify potential instances of inappropriate treatment or dosage in this demographic.
Main Methods:
- Cross-sectional study design utilizing data from the Kungsholmen Project.
- Inclusion of 1800 participants aged 75 years and over in Stockholm, Sweden.
- Data collection through interviews covering 22 different symptoms and actual drug use, analyzed via logistic regression.
Main Results:
- Pain and tiredness were the most frequently reported symptoms.
- Symptoms were generally more prevalent in women and older age groups.
- While many symptom-drug associations aligned with established treatments, some, like tiredness with anxiolytics/hypnotics, suggested potential issues.
Conclusions:
- Self-reported symptoms are common in the elderly, particularly pain and tiredness.
- Associations between symptoms and drug use highlight both effective treatments and potential areas for concern.
- Further investigation into specific drug-symptom relationships is warranted to ensure appropriate geriatric pharmacotherapy.
Related Concept Videos
Drug Abuse and Addiction: Pharmacological Phenomena
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Substance Use Disorders Affecting Sleep
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
Drug Dependence
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Drug Toxicity: Risk factors
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Prevalence and Incidence
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...

