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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Protection of Renal Function with ACE Inhibitors: Experience with Benazepril.
J C Aldigier1, Y L Meur, P Brunel
1Centre Hospitalier Régional Universitaire Dupuytren, Limoges, France.
Clinical Drug Investigation
|March 29, 2008
Summary
Angiotensin II (AII) significantly contributes to progressive renal scarring. ACE inhibition, like with benazepril, effectively slows kidney damage progression and is well-tolerated in patients with chronic kidney disease.
Area of Science:
- Nephrology
- Pharmacology
Background:
- Progressive renal scarring, including glomerulosclerosis and tubulointerstitial scarring, is closely linked to angiotensin II (AII).
- AII's role in renal scarring may be direct (proliferative, fibrogenic) or indirect via growth factors like PDGF and TGF-β1.
- ACE inhibition has emerged as a therapeutic strategy, preventing experimental renal scarring and slowing chronic renal failure in humans.
Purpose of the Study:
- To evaluate the protective effects of benazepril, an ACE inhibitor, against the progression of renal insufficiency.
- To assess the tolerability of benazepril in patients with various renal diseases.
Main Methods:
- The study involved patients with progressive renal insufficiency and various renal diseases.
- Benazepril was administered, and its effects on renal insufficiency progression were monitored.
- Patient tolerability to benazepril treatment was assessed.
Main Results:
- Benazepril demonstrated protection against the progression of renal insufficiency in patients with diverse renal diseases.
- The treatment was found to be well-tolerated among the study participants.
- The AIPRI study confirmed benazepril's renoprotective effects.
Conclusions:
- Benazepril, an ACE inhibitor, is effective in slowing the progression of renal insufficiency.
- Benazepril is a safe and well-tolerated treatment option for patients with chronic kidney disease and progressive renal scarring.
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