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Lipoprotein(a): nonhuman primate models.

K Makino1, A M Scanu

  • 1Department of Medicine, University of Chicago, Illinois 60637.

Lipids
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

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Lipoprotein(a) [Lp(a)] in nonhuman primates, like rhesus monkeys, is structurally similar to human Lp(a). These primates offer a valuable model for studying Lp(a) structure and biology, aiding atherogenicity and thrombogenicity research.

Area of Science:

  • Cardiovascular Biology
  • Lipid Metabolism
  • Primate Models

Background:

  • Lipoprotein(a) [Lp(a)] is a lipoprotein particle implicated in atherogenicity and thrombogenicity.
  • Apolipoprotein(a) [apo(a)] shows homology to plasminogen, increasing interest in Lp(a)'s biological mechanisms.

Purpose of the Study:

  • To investigate the presence and characteristics of Lp(a) in nonhuman primates.
  • To evaluate nonhuman primates as models for studying Lp(a) structure and biology.

Main Methods:

  • Comparative analysis of Lp(a) structure in nonhuman primates and humans.
  • Documentation of Lp(a) presence and variability in primate species.

Main Results:

  • Lp(a) is present in nonhuman primates, notably rhesus monkeys and baboons.

Related Experiment Videos

  • Rhesus monkey Lp(a) is structurally similar to human Lp(a), with minor differences in kringle V and catalytic regions.
  • Nonhuman primate Lp(a) exhibits interindividual variability in plasma levels and apo(a) size polymorphism.

    • Conclusions:

    • Nonhuman primates, particularly rhesus monkeys, possess Lp(a) with significant structural homology to human Lp(a).
    • These primates serve as a relevant and valuable model for advancing research into Lp(a) structure, biology, and associated cardiovascular risks.