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Related Experiment Video

Updated: Jul 6, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

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Published on: August 15, 2020

Enteric neurodegeneration in ageing.

M Camilleri1, T Cowen, T R Koch

  • 1Department of Medicine and Physiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. camilleri.michael@mayo.edu

Neurogastroenterology and Motility
|March 29, 2008
PubMed
Summary
This summary is machine-generated.

Degeneration of the enteric nervous system, a cause of constipation in older adults, involves loss of excitatory neurons. Research into neurotrophins and 5-HT mechanisms may offer future treatments.

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Area of Science:

  • Neurobiology
  • Gastroenterology

Context:

  • Ageing populations frequently experience constipation, incontinence, and evacuation disorders.
  • Healthy lower gastrointestinal function is vital for maintaining independence and autonomy in older adults.
  • Enteric neurodegeneration contributes to these functional disturbances.

Purpose:

  • To review the clinical presentation and neurobiology of enteric nervous system degeneration.
  • To emphasize human data and explore potential therapeutic targets.
  • To understand the role of neurodegeneration in age-related gastrointestinal dysfunction.

Summary:

  • Enteric neurodegeneration, a key factor in constipation, involves the loss of excitatory (cholinergic) neurons and interstitial cells of Cajal, while inhibitory neurons remain unaffected.
  • Neurotrophins show potential in accelerating colonic transit and relieving constipation, possibly through antioxidant defense mechanisms.
  • Serotonin receptors 5-HT(2) and 5-HT(4) play a role in enteric neuron development, maintenance, and survival.

Impact:

  • Understanding enteric neurodegeneration is crucial for developing treatments to reverse age-related gastrointestinal disorders.
  • Further research on neurotrophins in the ageing colon is needed.
  • Investigating 5-HT mechanisms may lead to novel therapeutic strategies for enteric neurodegeneration.