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Related Experiment Videos

[Early failure in kidney transplantation].

M Hourmant1, J Chanard, D Durand

  • 1Service de Néphrologie-Immunologie Clinique, CHRU, Hôtel-Dieu, Nantes.

Presse Medicale (Paris, France : 1983)
|November 27, 1991
PubMed
Summary

Early kidney transplant failure is linked to donor and recipient age under five, and pre-transplant immunization. These factors, along with HLA compatibility in hyperimmunized patients, significantly impact graft survival but aren't specific to early loss.

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Physical review letters·2019

Area of Science:

  • Nephrology
  • Transplant Surgery
  • Immunology

Context:

  • Analysis of 507 early kidney transplant failures (first month) from 7541 cadaveric transplants (France, 1985-1989).
  • Early failures constituted 6.7% of all transplants, 68.6% of first 3-month failures, and 47% of first-year failures.

Purpose:

  • To identify significant risk factors for early graft loss in kidney transplantation.
  • To determine if identified risk factors are specific to early transplant failure.

Summary:

  • Donor sex, recipient sex, ABO group, kidney origin, cold ischemia time, HLA compatibility, dialysis duration, and prior transplant history did not influence early failure.
  • Significant risk factors for early graft loss include: donor age < 5 years (P=0.00001), recipient age < 5 years (P=0.05), and pre-transplant immunization (P=0.002).

Related Experiment Videos

  • Multifactorial analysis revealed that lack of HLA compatibility in hyperimmunized patients also significantly influences early graft loss.

    • Impact:

    • The identified risk factors (pediatric donor/recipient age, pre-transplant immunization, HLA incompatibility in hyperimmunized patients) have a longstanding influence on graft survival.
    • These factors are not specific to early graft loss, indicating their broader impact on long-term kidney transplant outcomes.