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Immunization of Alpacas (Lama pacos) with Protein Antigens and Production of Antigen-specific Single Domain Antibodies

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Published on: January 26, 2019

Thrombotic endocarditis in 10 alpacas.

A M Firshman¹, A Wünschmann, C K Cebra

¹Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA. anna.firshman@oregonstate.edu

Journal of Veterinary Internal Medicine

|March 29, 2008

Summary

This summary is machine-generated.

Thrombotic endocarditis in alpacas often presents with non-specific signs like abdominal distension. This serious condition, characterized by mural thrombi, has a grave prognosis and is linked to hepatic fluke infestation.

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Immunization of Alpacas (Lama pacos) with Protein Antigens and Production of Antigen-specific Single Domain Antibodies

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Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation

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Published on: September 24, 2021

Area of Science:

Veterinary Cardiology
Comparative Pathology
Alpaca Medicine

Background:

This study describes clinical and necropsy findings in ten alpacas diagnosed with thrombotic endocarditis.
Cases were retrospectively identified from two veterinary referral hospitals between 1998 and 2006.

Observation:

Common clinical signs included sternal recumbency, tachycardia, tachypnea, and abdominal distension.
Cardiac auscultation was normal in most alpacas; effusions and ascites were frequent.
Hematological and biochemical analyses often indicated inflammation and increased liver enzymes.

Findings:

Echocardiography revealed soft tissue density in the right ventricle.
Necropsy showed mural endocarditis with fibrinous thrombi, predominantly in the right ventricle, without valvular involvement in most cases.
Hepatic fluke infestation was noted in eight alpacas; bacterial causes were not consistently identified.

Implications:

Thrombotic endocarditis should be considered in alpacas with signs of right-sided congestive heart failure, hepatomegaly, and abdominal distension.
The disease carries a grave prognosis in alpacas.
Hepatic fluke infestation may be a contributing factor.