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Updated: Jul 6, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Hidden respiratory disease-associated deaths.

R Perez-Padilla¹

¹National Institute of Respiratory Diseases of Mexico, Tlalpan, México. perezpad@servidor.unam.mx

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease

|March 29, 2008

Summary

Many respiratory disease deaths are misclassified in the International Classification of Diseases (ICD-10). This study reveals a significant number of hidden respiratory deaths, impacting public health assessments.

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Last Updated: Jul 6, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Area of Science:

Public health
Epidemiology
Respiratory medicine

Background:

Respiratory diseases represent a significant global health burden.
Accurate mortality data is crucial for understanding disease impact and allocating resources.
The International Classification of Diseases (ICD-10) is used for disease coding and mortality statistics.

Purpose of the Study:

To consolidate all respiratory-related deaths, regardless of their ICD-10 code.
To provide a more accurate assessment of the public health significance of respiratory diseases.
To identify respiratory deaths misclassified in the ICD-10 system.

Main Methods:

Analysis of the World Health Organization's disaggregated mortality database.
Inclusion of data from 86 countries using the ICD-10 classification.
Comprehensive review of mortality codes related to respiratory conditions, including airways and thorax.

Main Results:

Respiratory conditions accounted for 16.6% of deaths in analyzed countries.
61% of respiratory deaths were classified as chronic respiratory ailments.
A substantial 44% of respiratory deaths were coded outside the primary respiratory group (Group J), with 7.8% hidden in other codes.

Conclusions:

A significant proportion of respiratory deaths are 'hidden' within various ICD-10 codes.
These hidden deaths are more prevalent in countries with high acute respiratory disease rates and low chronic rates.
The misclassification necessitates a re-evaluation of respiratory disease burden and public health strategies.