Related Experiment Video

Updated: Jul 6, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Rotavirus morbidity and mortality in children in Brazil

Ana Marli Christovam Sartori1, Joice Valentim, Patrícia Coelho de Soárez

  • 1Clínica de Moléstias Infecciosas e Parasitárias, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil. anasartori@gmail.com

Revista Panamericana De Salud Publica = Pan American Journal of Public Health
|March 29, 2008
PubMed

Insights

Rotavirus infections caused significant child morbidity and mortality in Brazil before vaccine introduction. In 2004, an estimated 850 deaths and over 92,000 hospitalizations in children under six were linked to rotavirus gastroenteritis.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health Epidemiology

Background:

  • Rotavirus is a leading cause of severe diarrheal disease in young children globally.
  • Understanding pre-vaccine rotavirus burden is crucial for evaluating public health interventions.
  • Brazil's National Immunization Program (PNI) introduced the rotavirus vaccine in 2006.

Purpose of the Study:

  • To determine the epidemiology of rotavirus.
  • To estimate rotavirus-associated morbidity and mortality in Brazilian children under six years old.
  • To establish a baseline before rotavirus vaccine introduction into the PNI.

Main Methods:

  • Systematic review of published studies (1999-2006) on diarrhea incidence and rotavirus frequency in children under six.
  • Classification of diarrhea severity into mild, moderate, and severe (hospitalization) based on care level.
  • Analysis of national mortality data (Mortality Information System, SIM) to determine rotavirus proportion of diarrhea deaths.

Main Results:

  • Estimated 3,525,053 annual rotavirus diarrhea episodes in children under six.
  • Estimated 655,853 outpatient visits and 92,453 hospitalizations annually due to rotavirus.
  • Estimated 850 annual rotavirus-associated deaths in children under six.

Conclusions:

  • Rotavirus infections represent a substantial public health burden in Brazil.
  • The findings highlight the significant impact of rotavirus on child morbidity and mortality.
  • This data provides essential pre-vaccination epidemiological context for Brazil.
Abstract

More Related Videos

Breakfast Habits among Schoolchildren in the City of Uruguaiana, Brazil06:48

Breakfast Habits among Schoolchildren in the City of Uruguaiana, Brazil

Published on: July 29, 2020

Related Concept Videos

Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...