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Riding the waves: neural and nonneural origins for mesenchymal stem cells

Freda D Miller1

  • 1Developmental and Stem Cell Biology Program, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada. fredam@sickkids.ca

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Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...