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Updated: Jul 6, 2026

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
Published on: July 29, 2015
The first direct reprogramming of adult human fibroblasts
1Scottish Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, UK. ian.wilmut@ed.ac.uk
Abstract:
In recent issues of Cell and Science, Yamanaka and colleagues (Takahashi et al., 2007) and Yu and colleagues (Yu et al., 2007) demonstrate that expression of four specific transcription factors gives adult human fibroblasts many of the characteristics of human embryonic stem cells. Refinements of this procedure will make it possible to produce pluripotent human cell lines without use of an embryo. There are profound scientific and social implications of this research.
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