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Updated: Jul 6, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Knocking the Wnt out of the sails of leukemia stem cell development
Aniruddha J Deshpande1, Christian Buske
1Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany.
Abstract:
Tumor propagation by cancer stem cells (CSCs) requires their ability to self-renew, and yet the signal pathways involved in this process remain poorly defined. In the December issue of Cancer Cell, Zhao et al. (2007) provide compelling evidence that Wnt/beta-catenin signaling is crucial for the maintenance of chronic myelogenous leukemia (CML) stem cells.
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