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Hematopoiesis

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Overview of Hematopoiesis

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...

Production of Formed Elements

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...

Source And Potency Of Stem Cells

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: Jul 6, 2026

Isolation and Analysis of Hematopoietic Stem Cells from the Placenta

Isolation and Analysis of Hematopoietic Stem Cells from the Placenta

Published on: June 24, 2008

Are hematopoietic stem cells generated in the placenta?

Aurelie Kieusseian¹, Ana Cumano

¹Department of Immunology, Pasteur Institute, 25 rue du Dr. Roux, Paris 75015, France.

|March 29, 2008

Summary

Multipotent hematopoietic stem cells in the placenta were studied in embryos without heart function. Researchers found lymphoid progenitors in the placenta, suggesting they originate there.

Area of Science:

Developmental biology
Hematopoiesis
Stem cell research

Background:

Investigating the origin of multipotent hematopoietic cells is crucial for understanding early development.
Previous studies have proposed various origins for these cells, but definitive evidence remains elusive.

Discussion:

This study examines hematopoietic stem cell origins in Ncx1(-/-) embryos, which lack heart and circulation, to determine if the placenta is a primary site.
The presence of lymphoid progenitors in the placenta, dorsal aorta, and yolk sac of these embryos suggests localized development.

Key Insights:

Lymphoid progenitors are found within the placenta of Ncx1(-/-) embryos.
These findings indicate that multipotent hematopoietic cells can arise in situ within the placenta.

More Related Videos

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Published on: June 6, 2016

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Published on: June 17, 2016

Related Experiment Videos

Last Updated: Jul 6, 2026

Isolation and Analysis of Hematopoietic Stem Cells from the Placenta

Isolation and Analysis of Hematopoietic Stem Cells from the Placenta

Published on: June 24, 2008

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Published on: June 6, 2016

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Published on: June 17, 2016

Outlook:

Further research is needed to fully elucidate the mechanisms of in situ hematopoietic stem cell development in the placenta.
Understanding these origins could have implications for regenerative medicine and stem cell therapies.