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Contactless conductivity detection for microfluidics: designs and applications.

Martin Pumera¹

¹ICYS, National Institute for Materials Science, 1-1 Namiki, Tsukuba 305-0044, Japan. PUMERA.Martin@nims.go.jp

|March 29, 2008

Summary

This review covers contactless conductivity detector (CCD) construction for microchip electrophoresis. It details three designs and discusses factors influencing performance for diverse applications.

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Area of Science:

Analytical Chemistry
Microfluidics
Instrumental Analysis

Background:

Contactless conductivity detectors (CCDs) are crucial for microchip electrophoresis (ME) devices.
Effective detection methods are needed for analyzing small sample volumes in microfluidic systems.

Purpose of the Study:

To review and describe various construction methods for contactless conductivity detectors (CCDs) in microchip electrophoresis.
To discuss key design considerations and influencing factors for CCD performance in microfluidic applications.

Main Methods:

Review of three primary CCD construction schemes for microchips.
Analysis of electrode placement (external, coplanar, buried) and insulation techniques.
Discussion of AC voltage parameters and their impact on detection.

Main Results:

Detailed description of three distinct CCD designs for microchip electrophoresis.
Identification of critical parameters affecting CCD performance, including electrode configuration and insulation.
Highlighting the versatility of CCDs in microchip electrophoresis for various analytical tasks.

Conclusions:

Multiple effective methods exist for constructing contactless conductivity detectors for microchip electrophoresis.
Optimizing electrode design, placement, and insulation is key to detector performance.
CCDs are versatile tools applicable to security, pharmaceutical, bioassay, and food analysis.