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Updated: Jul 6, 2026
Human Blastocyst Biopsy and Vitrification
Published on: July 26, 2019
Pregnancy after trophectoderm biopsy of frozen-thawed blastocyst
Ruth Bunker Lathi1, Barry Behr
1Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Stanford University Medical Center, Stanford, California 94305, USA. rlathi@stanford.edu
Objective:
To report a case of a successful pregnancy after trophectoderm biopsy and three-probe fluorescent in situ hybridization of a frozen blastocyst.
Design:
Techniques and instrumentation.
Setting:
A University Medical Center.
Patient(S):
Infertility patient desiring trophectoderm biopsy on frozen blastocyst for preimplantation testing, from an IVF cycle at a referring IVF program.
Intervention(S):
Frozen blastocysts were thawed the evening before the planned transfer. Trophectoderm biopsy was performed in the morning. The fluorescent in situ hybridization results were obtained the same day; embryo transfer was performed under ultrasound guidance.
Main Outcome Measurement(S):
Serum betahCG and transvaginal ultrasound.
Result(S):
Positive betahCG and ongoing pregnancy.
Conclusion(S):
Trophectoderm biopsy can be used as a means for testing frozen blastocysts in patients with excess embryos cryopreserved on day 5 or 6 from previously preformed IVF cycles.
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