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The role of the Saccharomyces cerevisiae Cdc7-Dbf4 complex in the replication checkpoint

Hiroo Ogi1, Cheng-Zhong Wang, Wataru Nakai

  • 1Laboratories for Biomolecular Networks, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan. oogi@fbs.osaka-u.ac.jp

Gene
|March 29, 2008
PubMed

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S-Cdk Initiates DNA Replication

The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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