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Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System
Published on: January 31, 2018
New ways to identify novel bacterial antigens for vaccine development
Abdolreza Reza Movahedi1, David J Hampson
1School of Veterinary and Biomedical Science, Murdoch University, South Street, Murdoch, Western Australia 6150, Australia.
Abstract:
This article provides an overview of developments in approaches to identify novel bacterial components for use in recombinant subunit vaccines. In particular it describes the processes involved in "reverse vaccinology", and some associated complementary technologies such as proteomics that can be used in the identification of new and potentially useful vaccine antigens. Results obtained from the application of these new methods are forming a basis for a new generation of vaccines for use in the control of bacterial infections of humans and animals.
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