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Effect of prolonged treatment with compression stockings to prevent post-thrombotic sequelae: a randomized controlled

Markus Aschwanden1, Christina Jeanneret, Michael T Koller

  • 1Department of Angiology, University Hospital Basel, Basel, Switzerland.

Journal of Vascular Surgery
|March 29, 2008
PubMed

Insights

Prolonged compression therapy after deep vein thrombosis may prevent skin changes and reduce symptoms. Further research is needed to determine its effectiveness in preventing advanced disease states like venous ulcerations.

Area of Science:

  • Vascular Medicine
  • Thrombosis Research
  • Dermatology

Background:

  • Deep vein thrombosis (DVT) is a significant vascular condition.
  • Post-thrombotic syndrome (PTS) is a common complication after DVT.
  • The efficacy of compression stockings in preventing PTS is debated.

Purpose of the Study:

  • To assess the effect of prolonged compression therapy after 6 months of standard treatment for acute proximal deep vein thrombosis.
  • To evaluate the prevention of post-thrombotic skin changes and symptoms.

Main Methods:

  • Randomized controlled trial involving 169 patients with proximal DVT.
  • Patients received 6 months of standard treatment, then allocated to compression stockings or no compression.
  • Primary endpoint: emerging skin changes (CEAP C4-C6); Secondary endpoint: PTS symptoms.
  • Intention-to-treat analysis was performed.

Main Results:

  • The primary endpoint occurred in 13.1% of the treatment group vs. 20.0% in the control group (HR, 0.60; 95% CI, 0.28-1.28; P = .19).
  • Significant symptom relief favoring compression was observed during the first year.
  • A notable sex-specific difference was found, with women benefiting more than men.

Conclusions:

  • Prolonged compression therapy shows potential in reducing symptoms and preventing skin changes after DVT.
  • The ability of compression therapy to prevent advanced PTS, including ulcerations, requires further investigation.
  • Findings suggest a potential benefit, particularly for women, in managing DVT sequelae.
Abstract

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