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[Sjögren's syndrome: therapeutic trends]
1Cattedra di Reumatologia, Università degli Studi di Ancona.
La Clinica Terapeutica
|November 15, 1991
Summary
Sjögren syndrome, an autoimmune disorder, impairs exocrine glands like salivary and lacrimal glands. While treatments exist, further research into dietary interventions like low-lipid diets is warranted for managing inflammation.
Area of Science:
- Rheumatology
- Immunology
- Ophthalmology
Context:
- Sjögren syndrome is an autoimmune disorder affecting exocrine glands, primarily salivary and lacrimal glands.
- It leads to functional impairment and secondary disorders due to hyposecretion.
- The condition is generally benign but can have systemic implications.
Purpose:
- To review current symptomatic treatments for Sjögren syndrome.
- To evaluate the efficacy of various therapeutic agents.
- To explore emerging dietary interventions for managing the disease.
Summary:
- Symptomatic treatments include hygienic measures and topical therapies to alleviate hyposecretion-related issues.
- Hydrochloroquine shows some laboratory improvements but limited clinical impact.
- Corticosteroids and immunosuppressants are reserved for severe, systemic cases.
- A low-lipid diet is being investigated for its potential anti-inflammatory effects and reduction of glandular lymphocyte infiltration.
Impact:
- Current treatments primarily manage symptoms and secondary complications.
- Hydrochloroquine offers limited clinical benefit.
- Severe cases require potent immunosuppressive therapy.
- Further research on low-lipid diets may reveal novel therapeutic strategies for Sjögren syndrome, potentially reducing inflammation and glandular damage.