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[Microbial intestinal biocenosis in lingering and complicated course of community pneumonia]

M Iu Osipov, A E Bilev, Iu A Osipov

    Terapevticheskii Arkhiv
    |April 1, 2008
    PubMed
    Abstract

    Insights

    Community pneumonia (CP) significantly alters intestinal microflora, leading to dysbacteriosis. Antibiotic use in complicated CP further disrupts gut balance, impacting disease course and necessitating fecal microflora analysis.

    Area of Science:

    • Microbiology
    • Pulmonology
    • Gastroenterology

    Background:

    • Community pneumonia (CP) is a significant health concern with complex courses.
    • Intestinal microflora plays a crucial role in overall health and immune function.
    • Dysbacteriosis, an imbalance in gut microbiota, is increasingly recognized as a factor in various diseases.

    Purpose of the Study:

    • To characterize the species and quantitative composition of intestinal microflora in patients with community pneumonia (CP).
    • To investigate the impact of lingering and complicated CP courses on intestinal microflora.
    • To assess the relationship between dysbacteriosis and CP severity and complications.

    Main Methods:

    • Enrolled 130 CP patients and 30 healthy controls for comparative analysis.
    • Classified CP severity (mild, moderate, severe) and identified complications (e.g., respiratory insufficiency, toxic shock, lung abscess).
    • Quantitatively and qualitatively analyzed intestinal microflora composition using standard microbiological techniques.

    Main Results:

    • Dysbacteriosis was prevalent in CP patients (42.3% acute, 18.8% convalescence), more severe in critical cases.
    • CP patients exhibited significantly lower levels of beneficial bacteria (Bifidobacteria, Enterococci, Escherichia) and a marked increase in Staphylococci.
    • Lingering pneumonia cases showed higher prevalence of specific E. coli strains and Staphylococci compared to mild acute CP.

    Conclusions:

    • Community pneumonia is strongly associated with significant intestinal dysbacteriosis.
    • Long-term antibiotic use in complicated CP exacerbates microflora imbalance, potentially worsening the disease.
    • Fecal microflora analysis is recommended for all CP patients, regardless of gastrointestinal symptoms, to guide management.

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