Related Experiment Video
Updated: Jul 6, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
[Immune system reactivity in patients with chronic hepatitis c]
Aim:
To determine levels of IL-1beta, IL-2, IL-4, IL-6, TNF-alpha, IFN-alpha, IFN-gamma in patients with chronic hepatitis C (CHC).
Material And Methods:
Peripheral blood cytokines were measured with enzyme immunoassay (Protein contour kits, St-Petersburg).
Results:
Higher content of IL-2, IFNa, IFNg was found in older patients with negative results of examination for HCV RNA, a/HCVcore IgM, a/HCV/ns3,5, genotype 3a, evidencing for higher reactivity of the immune system. High levels of IL-1beta, IL-6, TNFa were detected in young patients with narcotic drug consumption history, with high enxymatic activity, biliary inflammation, genotype 1b, high index of histological activity.
Conclusion:
The above changes characterize the severity of morphological, necrotic-inflammatory changes in the liver.
Related Concept Videos
Hepatitis
Viral Hepatitis I: Introduction
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Cell-mediated Immune Responses
Allergic Drug Reactions
Hypersensitivity Reactions: Cytolytic Reactions

