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Updated: Jul 6, 2026
Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
Published on: May 7, 2015
Hemodynamic alterations during orthotopic liver experimental transplantation in pigs
Orlando Jorge Martins Torres1, Patrícia Brandão Pantoja, Erica Sampaio Barbosa
1Department of Surgery, Federal University of Maranhão, Brazil. o.torres@uol.com.br
Purpose:
To describe the hemodynamic alterations during orthotopic liver transplantation in pigs.
Methods:
In the period from April 2004 to December 2005, forty-four female Landrace pigs, weighting between 32 and 38 Kg underwent orthotopic liver transplantation. The animals were divided into two groups, donor and recipient pairs, which received whole liver grafts. The surgical procedure was divided into four parts: harvested, back-table, hepatectomy of the recipient and implantation. We analyzed heart rate, blood gas, mean systemic arterial pressure (MAP-mmHg), central venous pressure, pH, Na-, K+, Cl-, Ca+ and urinary output.
Results:
The mean anhepatic time was 69 min, cold ischemia was 252.2 min and back-table was 56.6 min. Blood pressure and heart rate dropped significantly during anhepatic phase and after revascularization. Blood gas and electrolytes alterations were observed during anhepatic and reperfusion phases. Although alterations were noted during these phases, the hemodynamic status was recovered and stabilized in the end of the surgery.
Conclusions:
Simplified technique of liver transplant was achieved and description of hemodynamic alterations was possible in pigs.
