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Updated: Jul 6, 2026

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
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CXCR4 membrane expression in node-negative breast cancer.

Emmanuel Blot1, Sophie Laberge-Le Couteulx, Hossein Jamali

  • 1Département d'Oncologie Médicale, Centre Henri Becquerel, Rue d'Amiens, Rouen, France.

The Breast Journal
|April 1, 2008
PubMed
Summary

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CXC chemokine receptor 4 (CXCR4) membrane staining is a strong prognostic factor for metastasis-free and overall survival in node-negative breast cancer patients. Targeting CXCR4 may offer a new therapeutic strategy for primary breast cancer.

Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • CXC chemokine receptor 4 (CXCR4) plays a role in the organ-specific metastasis of breast cancer.
  • Understanding prognostic factors is crucial for tailoring breast cancer treatment strategies.

Purpose of the Study:

  • To investigate CXC chemokine receptor 4 (CXCR4) expression as a potential prognostic factor in primary breast cancer.
  • To evaluate the correlation between CXCR4 expression and patient survival outcomes.

Main Methods:

  • Retrospective analysis of 194 primary breast cancer patients treated in 1991.
  • Immunohistochemistry was used to assess CXCR4 membrane and cytoplasmic staining.
  • Standard prognostic factors and 10-year survival data were collected and analyzed.

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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Main Results:

  • CXCR4 membrane staining showed a significant association with improved 10-year metastasis-free survival (p < 0.0001) and overall survival (p < 0.0001) in node-negative breast cancer patients.
  • CXCR4 cytoplasmic staining did not demonstrate significant prognostic value.
  • No significant prognostic association was found for CXCR4 in node-positive breast cancer patients.

Conclusions:

  • CXCR4 membrane staining emerges as a novel and strong prognostic marker for node-negative primary breast cancer.
  • Targeting CXCR4 presents a potential new therapeutic avenue for primary breast cancer management.
  • Further research is warranted to validate these findings and explore therapeutic implications.