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Updated: Jul 6, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Mucosal tissue transglutaminase expression in celiac disease
Vincenzo Villanacci1, Tarcisio Not, Daniele Sblattero
1Second Pathology Department, Spedali Civili, Brescia, Italy. villanac@alice.it
Journal of Cellular and Molecular Medicine
|April 1, 2008
Summary
Tissue transglutaminase (tTG) is crucial in celiac disease. However, assessing tTG levels in duodenal biopsies is not a useful diagnostic tool for celiac disease or related duodenitis.
Area of Science:
- Gastroenterology
- Immunology
- Pathology
Background:
- Tissue transglutaminase (tTG) is implicated in celiac disease (CD) pathogenesis.
- Antibodies to tTG are diagnostic markers for gluten-sensitive enteropathy.
- Understanding tTG localization in the duodenum is key for CD diagnosis.
Purpose of the Study:
- To investigate the localization of tTG in duodenal mucosa.
- To compare tTG expression in celiac disease (CD) and control tissues.
- To evaluate the diagnostic utility of tTG assessment in CD.
Main Methods:
- Utilized a commercial and novel monoclonal antibodies against tTG.
- Analyzed duodenal biopsy samples from 18 untreated celiac patients and 11 controls with chronic duodenitis.
- Employed immunohistochemical methods to assess tTG distribution.
Main Results:
- tTG expression was consistent across different histological stages of CD.
- tTG levels were similar in CD patients and controls with duodenitis.
- Immunohistochemical assessment of tTG in biopsies did not differentiate CD from controls.
Conclusions:
- tTG expression levels in duodenal biopsies are not a reliable diagnostic marker for celiac disease.
- Immunohistochemical evaluation of tTG is not clinically useful for diagnosing CD.
- Further research may explore other diagnostic markers for celiac disease.
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