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Related Experiment Video

Updated: Jul 6, 2026

Extracellular Vesicle Tissue Factor Activity Assay

Extracellular Vesicle Tissue Factor Activity Assay

Published on: December 29, 2023

Tissue factor, angiogenesis and tumour progression.

Joanne E Bluff¹, Nicola J Brown, Malcolm W R Reed

¹Microcirculation Research Group, Academic Unit of Surgical Oncology, School of Medicine and Biomedical Sciences, Beech Hill Road, Sheffield S10 2RX, UK. j.bluff@sheffield.ac.uk

Breast Cancer Research : BCR

|April 1, 2008

Summary

Tissue factor initiates blood clotting and aids tumor progression. Research highlights its role in tumor hemostasis, angiogenesis, metastasis, and survival, paving the way for new anticancer therapies.

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Last Updated: Jul 6, 2026

Extracellular Vesicle Tissue Factor Activity Assay

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Published on: December 29, 2023

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

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Published on: December 21, 2014

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Area of Science:

Oncology
Hematology
Molecular Biology

Background:

Tissue factor (TF) is the main initiator of the coagulation cascade, crucial for vascular integrity after injury.
Emerging evidence indicates TF's involvement in tumor progression beyond its procoagulant role.

Purpose of the Study:

To review current evidence on tissue factor's role in tumor hemostasis, angiogenesis, metastasis, and cancer cell survival.
To discuss future research directions for understanding TF regulation and developing novel anticancer therapies.

Main Methods:

Literature review of recent studies on tissue factor in cancer.
Analysis of TF's procoagulant and non-hemostatic functions in malignant diseases.

Main Results:

Tissue factor promotes tumor hemostasis, supporting the tumor microenvironment.
TF contributes to tumor angiogenesis, facilitating new blood vessel formation.
Evidence links TF to enhanced metastasis and improved survival of malignant cells.

Conclusions:

Tissue factor plays a multifaceted role in cancer progression, acting as a key mediator.
Targeting tissue factor presents a promising strategy for developing innovative anticancer treatments.