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Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Complementation Tests00:49

Complementation Tests

A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...

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Related Experiment Video

Updated: Jul 6, 2026

Absolute Quantification of Plasma MicroRNA Levels in Cynomolgus Monkeys, Using Quantitative Real-time Reverse Transcription PCR
10:23

Absolute Quantification of Plasma MicroRNA Levels in Cynomolgus Monkeys, Using Quantitative Real-time Reverse Transcription PCR

Published on: February 12, 2018

Investigation of cynomolgus monkey complement.

H Xu1, E Kitano, Y Sato

  • 1Division of Organ Transplantation, Department of Molecular Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan.

Transplantation Proceedings
|April 1, 2008
PubMed
Summary
This summary is machine-generated.

Human decay accelerating factor (CD55) demonstrates similar complement regulatory function in both human and cynomolgus monkey sera. This finding is crucial for advancing xenotransplantation research using cynomolgus monkeys.

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Last Updated: Jul 6, 2026

Absolute Quantification of Plasma MicroRNA Levels in Cynomolgus Monkeys, Using Quantitative Real-time Reverse Transcription PCR
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Area of Science:

  • Immunology
  • Xenotransplantation Research

Background:

  • Cynomolgus monkeys are key recipients in xenotransplantation.
  • Limited research exists on cynomolgus monkey complement systems.
  • Complement regulation is vital for xenograft survival.

Purpose of the Study:

  • To investigate the complement regulatory function of human decay accelerating factor (CD55) in cynomolgus monkey serum.
  • To compare this function between human and cynomolgus monkey sera.

Main Methods:

  • Hemolytic complement titers were measured in cynomolgus monkeys using human-standard methods.
  • The regulatory function of human decay accelerating factor (CD55) was assessed on porcine endothelial cells (PECs) in both human and cynomolgus monkey sera.

Main Results:

  • Complement titers (CH50, ACH50, C2, C3) were generally high in cynomolgus monkeys, with C4 being an exception.
  • Human decay accelerating factor (CD55) exhibited comparable complement regulatory activity in both human and cynomolgus monkey sera when applied to porcine endothelial cells.

Conclusions:

  • Human decay accelerating factor (CD55) functions similarly in regulating complement in both human and cynomolgus monkey sera.
  • This suggests potential for using human CD55 to mitigate complement-mediated rejection in cynomolgus monkey xenotransplantation models.