Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Vitamins

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...

Venous Thrombosis I: Introduction

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Targeting Extended Thromboprophylaxis after Surgery Through Multidimensional Dynamic Pulmonary Embolism Risk Assessment: Development and Temporal Validation in 4.8 Million Operations.

Journal of the American College of Surgeons·2026

Same author

Annals Consult Guys - A Case of Two Stenoses: Aortic and Spinal.

Annals of internal medicine·2026

Same author

Annals Consult Guys - Deep Venous Thrombosis in a Patient With Cancer.

Annals of internal medicine·2026

Same author

Annals Consult Guys - A Landscaper With Abdominal Pain.

Annals of internal medicine·2026

Same author

Great Debates in Vascular Medicine: Interventional therapy for iliofemoral DVT and anticoagulation regimen after iliac stenting.

Vascular medicine (London, England)·2026

Same author

Annals Consult Guys - Colonoscopy and Anticoagulation: A Challenging Combination.

Annals of internal medicine·2026

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

Ferric Chloride-induced Murine Thrombosis Models

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

Vitamin K and thrombosis.

Geno J Merli¹, James Fink

¹Professor of Medicine, Director Jefferson Center for Vascular Diseases, Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.

Vitamins and Hormones

|April 1, 2008

Summary

Vitamin K, essential for blood clotting and bone health, plays a crucial role in managing warfarin anticoagulation. Emerging research highlights its significance in cell metabolism, posing new clinical questions.

Area of Science:

Biochemistry
Nutritional Science
Hematology

Background:

Vitamin K, a fat-soluble vitamin, exists as phylloquinone (K1) in plants and menaquinone (K2) produced by gut bacteria.
It is vital for hemostasis (blood clotting) and its deficiency causes conditions like hemorrhagic disease of the newborn.
Warfarin, a vitamin K antagonist, is widely used for thrombotic conditions but carries a bleeding risk, making vitamin K a key reversal agent.

Purpose of the Study:

To review the historical discovery and established roles of vitamin K.
To highlight the critical function of vitamin K in warfarin reversal.
To introduce emerging research areas concerning vitamin K's involvement in cellular processes.

Main Methods:

Literature review of vitamin K's discovery, function, and clinical applications.

More Related Videos

Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis

Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis

Published on: March 17, 2023

Related Experiment Videos

Last Updated: Jul 6, 2026

Ferric Chloride-induced Murine Thrombosis Models

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis

Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis

Published on: March 17, 2023

Analysis of vitamin K's role as an antagonist to warfarin.

Exploration of recent research trends in vitamin K metabolism.

Main Results:

Vitamin K is essential for normal hemostasis and its deficiency leads to specific clinical disorders.
Vitamin K is a crucial agent for reversing warfarin-induced anticoagulation, managing bleeding risks.
New research indicates vitamin K's involvement in bone and vascular metabolism, cell growth, and apoptosis.

Conclusions:

Vitamin K remains fundamental for hemostasis and critical in managing anticoagulant therapy.
Ongoing research into vitamin K's broader metabolic roles necessitates further clinical investigation.
Understanding vitamin K's multifaceted functions is key for optimizing patient care, especially those on long-term warfarin.