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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 29, 2010

Oestrogen and the colon: potential mechanisms for cancer prevention

Rory Kennelly1, Dara O Kavanagh, Aisling M Hogan

  • 1Department of Surgery, St Vincent's University Hospital, Dublin, Ireland. kennellyrory@yahoo.ie

The Lancet. Oncology
|April 1, 2008
PubMed

Insights

Oestrogen

Area of Science:

  • Oncology
  • Endocrinology
  • Gastroenterology

Background:

  • Oestrogen's role in breast cancer is well-established, with modulators used in treatment.
  • Oestrogen signalling in colon cancer is poorly understood, despite men's higher susceptibility.
  • Hormone replacement therapy shows a protective effect in postmenopausal women, correlating with less aggressive disease.

Purpose of the Study:

  • To review current hypotheses on oestrogen's role in colon cancer.
  • To examine cellular and molecular mechanisms of oestrogen's purported protective influence.
  • To assess evidence supporting oestrogen's protective effects in colon cancer.

Main Methods:

  • Literature review of published studies on oestrogen and colon cancer.
  • Analysis of cellular and molecular mechanisms.
  • Evaluation of existing evidence for oestrogen's role.

Main Results:

  • Oestrogen receptor beta (ERbeta) is overexpressed in healthy colon but reduced in colon cancer.
  • Hypotheses suggest oestrogen may exert a protective influence.
  • Evidence for these protective mechanisms is under review.

Conclusions:

  • The precise role of oestrogen and ERbeta in colon cancer pathogenesis requires further elucidation.
  • Understanding these mechanisms could lead to novel therapeutic strategies.
  • Further research is needed to confirm oestrogen's protective role and its clinical implications.

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