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Fight or learn to live with the consequences?

Michael Boots1

  • 1Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield, UK. m.boots@sheffield.ac.uk

Trends in Ecology & Evolution
|April 1, 2008
PubMed

Insights

Host tolerance, a way to reduce disease severity without killing pathogens, varies among mouse strains. This study found that increased tolerance to malaria in mice was linked to decreased resistance, highlighting tolerance

Area of Science:

  • * Host-parasite interactions and evolutionary biology.
  • * Immunology and infectious disease research.

Background:

  • * Infectious disease control involves resistance (pathogen growth reduction) and tolerance (disease amelioration).
  • * Tolerance is a crucial but understudied host defense mechanism in animal models.
  • * Understanding tolerance is key to comprehending host-parasite coevolutionary dynamics.

Purpose of the Study:

  • * To investigate variation in disease tolerance among different mouse strains.
  • * To examine the relationship between tolerance and resistance to infectious diseases.
  • * To highlight the significance of tolerance in host-pathogen dynamics.

Main Methods:

  • * Utilized different mouse strains to assess natural variation in disease tolerance.
  • * Measured tolerance to a specific pathogen (rodent malaria).
  • * Quantified pathogen load and disease severity to determine tolerance levels.

Main Results:

  • * Significant variation in malaria tolerance was observed across mouse strains.
  • * A negative correlation was found between tolerance and resistance.
  • * Mice with higher tolerance exhibited greater disease severity despite pathogen control.

Conclusions:

  • * Disease tolerance is a variable trait in animal populations.
  • * Tolerance and resistance are not always complementary and can be inversely related.
  • * Further research into tolerance mechanisms is essential for understanding infectious disease epidemiology and evolution.

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