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Adult and Pediatric Porcine Model of Acute Volume Overload
Published on: January 12, 2024
Pediatric population size is associated with geographic patterns of acute respiratory infections among adults
John S Brownstein1, Kenneth D Mandl
1Division of Emergency Medicine, Children's Hospital Boston; Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology, Boston, MA 02215, USA. john_brownstein@harvard.edu
Insights
The proportion of children in a community is linked to when and how often adults use emergency departments for respiratory infections. Younger children, particularly 3- to 4-year-olds, significantly influence adult illness patterns and onset timing.
Area of Science:
- Epidemiology
- Public Health
- Infectious Disease Transmission
Background:
- Adult emergency department (ED) utilization for acute respiratory infections (ARIs) is a significant public health concern.
- Understanding community-level factors influencing ARI transmission is crucial for effective public health interventions.
Purpose of the Study:
- To investigate the association between the proportion of children in a population and the timing and rate of adult ED visits for influenza and other ARIs.
- To identify specific pediatric age groups that may be key drivers of community-wide ARI transmission.
Main Methods:
- An ecologic time-series study was conducted using adult ED visit data from Massachusetts (2001-2005).
- ARI-related ED visits were aggregated by ZIP code and correlated with US Census pediatric population data.
- Poisson regression analysis was employed to assess the relationship between pediatric population proportions and adult ARI ED utilization.
Main Results:
- Over 157,000 adult ARI-related ED visits were analyzed.
- A higher proportion of children in a ZIP code was directly associated with earlier seasonal onset of adult ARIs (RR 0.985) and increased adult ARI ED utilization rates (RR 1.035).
- The 3- to 4-year-old age group emerged as the most significant predictor for adult illness rates and timing of onset.
Conclusions:
- A positive correlation exists between the proportion of children in a community and adult ED utilization for ARIs.
- Findings support the critical role of children in the community-wide transmission of acute respiratory infections.
- This highlights the importance of considering pediatric populations in public health strategies for managing infectious diseases.
Study Objectives:
We measure the association between proportion of children and specific pediatric age groups in a local population with the timing and rate of adult emergency department (ED) utilization for influenza and other acute respiratory infections.
Methods:
We performed an ecologic study on a time-series of adult patients presenting to Massachusetts EDs and residing in the greater Boston area from October 1, 2001, to September 30, 2005. Patients presenting with acute respiratory infection, used as a marker for influenza, were aggregated by home address ZIP code. We measured geographic patterns of timing and rate of adult respiratory infection-related ED utilization. We performed correlation analysis of rates and peaks identified in this analysis with pediatric population data from the US census (including specific pediatric age groups) by Poisson regression.
Results:
One hundred fifty seven thousand five hundred forty two adult respiratory infection-related ED visits (30 visits per 1,000 adults per year) were analyzed. Visits were distributed across 55 of ZIP codes, in which proportions of children (aged 0 to 18 years) ranged from 2.7% to 34.9% in these communities. Proportion of children in a ZIP code was directly associated with timing of seasonal onset of acute respiratory infections among adults (univariate Poisson regression rate ratio [RR] 0.985; 95% confidence interval [CI] 0.977 to 0.993). The proportion of children also explained the patterns of adult acute respiratory infection-related ED utilization rates (RR 1.035; 95% CI 1.024 to 1.047). Three- to 4-year-olds were found to be the most significant predictors of adult illness rate (RR 1.380; 95% CI 1.238 to 1.539) and timing of onset (RR 0.881; 95% CI 0.816 to 0.952).
Conclusion:
We demonstrate a positive correlation between the timing and rate of ED utilization by adults and the proportion of children in the population. These findings add to a growing body of evidence supporting a critical role played by children in community-wide transmission of acute respiratory infections.
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