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Prevalence of group C rotavirus among children in Rhode Island, United States

Mathew D Esona1, Charles D Humphrey, Penelope H Dennehy

  • 1Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|April 1, 2008
PubMed

Insights

Group C rotavirus contributes to childhood diarrhea in Rhode Island. This study identified group C rotavirus in 4.0% of pediatric gastroenteritis cases, highlighting its role in severe illness.

Area of Science:

  • Virology
  • Pediatric Gastroenterology
  • Epidemiology

Background:

  • Group C rotavirus (RVC) is a known cause of human gastroenteritis, but its epidemiological significance in children is not well-defined.
  • Understanding the burden of RVC is crucial for public health interventions.

Purpose of the Study:

  • To determine the prevalence and impact of RVC gastroenteritis in children under 10 years old in Rhode Island, USA.
  • To investigate the role of RVC as a cause of acute diarrhea in a pediatric population.

Main Methods:

  • Stool samples from 124 children with diarrhea were analyzed using enzyme immunoassay (EIA), nested PCR, and Southern hybridization.
  • Specific primers and probes targeting the VP7 gene of human RVC were employed.
  • Electron microscopy (EM) was used to examine RVC-positive samples.

Main Results:

  • Rotavirus was detected in 59.0% of samples; 42.7% were group A rotavirus (RVA), 4.0% were RVC, and 12.1% were co-infected with both RVA and RVC.
  • EM revealed damaged or empty rotavirus-like particles in RVC-positive specimens.

Conclusions:

  • Group C rotavirus is identified as a significant cause or contributing factor to diarrhea in both infants and older children in Rhode Island.
  • These findings underscore the importance of considering RVC in the diagnosis and management of pediatric gastroenteritis.
Abstract

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