Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cancer cachexia: developing multimodal therapy for a multidimensional problem.

K C H Fearon1

  • 1Clinical and Surgical Sciences (Surgery), School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh, United Kingdom. k.fearon@ed.ac.uk

European Journal of Cancer (Oxford, England : 1990)
|April 1, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross sectional imaging of truncal and quadriceps muscles relates to different functional outcomes in cancer.

Clinical nutrition (Edinburgh, Scotland)·2019
Same author

Prediction of 90 Day and Overall Survival after Chemoradiotherapy for Lung Cancer: Role of Performance Status and Body Composition.

Clinical oncology (Royal College of Radiologists (Great Britain))·2017
Same author

Influence of body composition profile on outcomes following colorectal cancer surgery.

The British journal of surgery·2016
Same author

Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for anaesthesia practice.

Acta anaesthesiologica Scandinavica·2015
Same author

Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 1: pathophysiological considerations.

Acta anaesthesiologica Scandinavica·2015
Same author

Emerging therapeutic concepts for muscle and bone preservation/formation.

Bone·2015
Same journal

Early-onset colorectal cancer across Europe: Burden, mechanisms, and health-system implications.

European journal of cancer (Oxford, England : 1990)·2026
Same journal

Clinical urgency of incidental findings in the first year of the 4-IN-THE-LUNG-RUN lung cancer screening program.

European journal of cancer (Oxford, England : 1990)·2026
Same journal

Clinically relevant endpoints and quality-of-life outcomes with darolutamide in patients with metastatic hormone-sensitive prostate cancer: Analyses of the phase III ARASENS trial.

European journal of cancer (Oxford, England : 1990)·2026
Same journal

Mapping the anatomical landscape of colorectal tumours: Location-specific efficacy of anti-epidermal growth factor receptor antibodies: Pooled analysis of randomised trials.

European journal of cancer (Oxford, England : 1990)·2026
Same journal

Left behind but not left alone: Excluded cell populations in the non-small cell lung cancer stroma predict superior long-term overall survival.

European journal of cancer (Oxford, England : 1990)·2026
Same journal

Survival outcomes of adjuvant therapy in resected stage III melanoma: Results from a real-life cohort study (TAMARIS).

European journal of cancer (Oxford, England : 1990)·2026
See all related articles

Cancer cachexia, a complex syndrome, involves weight loss and inflammation. Multimodal treatments can improve nutritional status and quality of life in advanced cancer patients.

Area of Science:

  • Oncology and Metabolism
  • Understanding the molecular underpinnings of cancer cachexia.

Background:

  • Cancer cachexia is a complex syndrome with early weight loss (pre-cachexia) progressing to severe debilitation.
  • Molecular insights from animal models reveal host-tumour interactions, neuro-hormonal appetite control, and muscle-wasting pathways.
  • Key human features include weight loss, reduced food intake, and systemic inflammation, guiding classification and therapeutic targets.

Purpose of the Study:

  • To review the current understanding of cancer cachexia, including its molecular basis, clinical features, and management strategies.
  • To highlight the potential of multimodal interventions and novel biomarkers in improving patient outcomes.
  • To advocate for new complex intervention studies in managing cancer cachexia.

Main Methods:

Related Experiment Videos

  • Review of molecular mechanisms in animal models (host-tumour interaction, neuro-hormonal control, muscle-wasting pathways).
  • Analysis of key defining features in human cachexia (weight loss, reduced food intake, inflammation).
  • Evaluation of evidence for multimodal approaches and novel biomarkers in patient stratification and trial design.

Main Results:

  • Molecular insights provide new biomarkers and therapeutic targets for cancer cachexia.
  • Human cachexia features offer a framework for classification and therapeutic rationale.
  • Multimodal interventions show potential to stabilize or improve nutritional status, function, and quality of life.
  • Novel biomarkers and techniques are advancing clinical trial design.

Conclusions:

  • Multimodal approaches addressing key issues can improve outcomes for advanced cancer patients with cachexia.
  • New biomarkers and measurement techniques are crucial for future clinical trial design.
  • There is a strong evidence base supporting complex intervention studies for cancer cachexia management.