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Related Experiment Videos

Lymphopenia and decrease in the total number of circulating CD3+ and CD4+ T cells during 'long-term' PUVA treatment

G Borroni1, C Zaccone, G Vignati

  • 1Department of Human and Hereditary Pathology, University of Pavia, IRCCS Policlinico S. Matteo, Italy.

Dermatologica
|January 1, 1991
PubMed
Summary

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Long-term psoralen plus ultraviolet A (PUVA) therapy for psoriasis significantly reduces the total number and percentage of circulating lymphocytes, including CD3+ and CD4+ T cells. Careful monitoring of T lymphocyte subsets is recommended for patients undergoing extended PUVA treatment.

Area of Science:

  • Dermatology
  • Immunology
  • Phototherapy

Background:

  • Psoriasis is a chronic inflammatory skin condition.
  • Psoralen plus ultraviolet A (PUVA) is a common photochemotherapy for severe psoriasis.
  • The long-term effects of PUVA on peripheral T lymphocyte subsets are not fully understood.

Purpose of the Study:

  • To investigate the relationship between high-dose PUVA treatment and peripheral T lymphocyte subsets in psoriatic patients.
  • To compare T lymphocyte subset levels in untreated psoriatic patients, long-term PUVA-treated patients, and healthy controls.

Main Methods:

  • Study included 19 treatment-naïve psoriatic patients and 13 long-term PUVA-treated psoriatic patients undergoing maintenance therapy.
  • Peripheral blood samples were analyzed for total lymphocyte count, percentage, and T lymphocyte subsets (CD3+, CD4+).

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  • Comparison was made with healthy controls and between patient groups.

    • Main Results:

    • No significant differences in lymphocyte parameters were observed between untreated psoriatic patients and healthy controls.
    • Long-term PUVA treatment led to a significant reduction in the total number and percentage of lymphocytes compared to untreated patients and controls.
    • A significant decrease in the total number of CD3+ and CD4+ T cells was noted in long-term PUVA-treated patients versus untreated patients.

    Conclusions:

    • Long-term PUVA therapy is associated with a significant reduction in circulating T lymphocytes, particularly CD3+ and CD4+ subsets.
    • These findings highlight the potential immunomodulatory effects of extended PUVA treatment.
    • Regular monitoring of T lymphocyte subsets is advisable for psoriatic patients receiving long-term PUVA therapy to assess potential long-term impacts.