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Updated: Jul 6, 2026
08:08
Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Genomics and proteomics in predicting cancer outcomes
Alexander A Parikh1, J Chad Johnson, Nipun B Merchant
1Vanderbilt University School of Medicine, 597 PRB, 2220 Pierce Avenue, Nashville, TN 37232, USA.
Surgical Oncology Clinics of North America
|April 1, 2008
Summary
Genomic and proteomic technologies revolutionize disease understanding, enabling targeted therapies. Challenges in integration and validation remain for clinical application of these powerful diagnostic tools.
Area of Science:
- Biotechnology
- Genomics
- Proteomics
Background:
- Human genome sequencing and genomic data acquisition have advanced disease understanding.
- Genomic and proteomic technologies offer new avenues for disease diagnosis and treatment.
Purpose of the Study:
- To summarize technologies and potential clinical applications of genomics and proteomics in disease.
- To highlight the challenges associated with integrating and validating these advanced techniques.
Main Methods:
- Review of current genomic and proteomic technologies.
- Analysis of potential clinical applications in diagnostics and targeted therapy.
- Identification of challenges in standardization and validation.
Main Results:
- Genomics and proteomics provide opportunities for disease diagnosis, classification, and targeted therapy.
- These technologies enhance understanding of tumor behavior.
- Integration, standardization, and validation pose significant challenges.
Conclusions:
- Genomics and proteomics are powerful tools for revolutionizing disease understanding and treatment.
- Further work is needed to overcome technical and validation hurdles for widespread clinical adoption.
- Standardization and validation are critical for realizing the full potential of these technologies.
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