Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extra-Mitral Abnormalities in Non-Syndromic Mitral Valve Prolapse assessed by Cardiovascular Magnetic Resonance.

The Canadian journal of cardiology·2026
Same author

Outcomes after tricuspid transcatheter edge-to-edge repair: a systematic review and meta-analysis.

Annals of cardiothoracic surgery·2026
Same author

Cardio-kidney-metabolic overlap in patients with severe heart failure: Data from the HELP-HF registry.

American heart journal·2026
Same author

Pulsed field ablation vs. thermal ablation for pulmonary vein isolation: a network meta-analysis of randomized controlled trials.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same author

From obesity to cardiovascular disease: pathological basis and clinical implications.

The American journal of medicine·2026
Same author

Impact of an intensive follow-up program on the outcome of acute heart failure patients hospitalized in internal medicine versus cardiology units: a single-center retrospective cohort study.

Internal and emergency medicine·2026

Related Experiment Video

Updated: Jul 6, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

MicroRNAs control gene expression: importance for cardiac development and pathophysiology.

Daniele Catalucci1, Michael V G Latronico, Gianluigi Condorelli

  • 1Department of Medicine, Division of Cardiology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0613, USA.

Annals of the New York Academy of Sciences
|April 1, 2008
PubMed
Summary

MicroRNAs (miRNAs) regulate cardiac hypertrophy. Suppressing miRNA-133 in vivo caused significant cardiac hypertrophy, suggesting therapeutic potential for heart disease treatments.

More Related Videos

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Related Experiment Videos

Last Updated: Jul 6, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Area of Science:

  • Molecular Biology
  • Cardiovascular Research
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression.
  • Emerging evidence implicates miRNAs in fundamental biological processes, including cardiac development and disease.
  • Specific miRNAs, like miRNA-1 and miRNA-133, are crucial for cardiac function.

Purpose of the Study:

  • To investigate the role of miRNA-1 and miRNA-133 in cardiac hypertrophy.
  • To explore the potential of miRNA modulation as a therapeutic strategy for heart disease.

Main Methods:

  • Bioinformatic analysis to predict miRNA targets.
  • In vitro and in vivo studies using cell cultures and murine models.
  • Experimental suppression of miRNA-133 using antagomir-133 oligonucleotides.

Main Results:

  • miRNA-1 and miRNA-133 expression inversely correlates with cardiac hypertrophy.
  • Knockout of miRNA-1 is associated with cardiac defects.
  • In vivo suppression of miRNA-133 induced significant and sustained cardiac hypertrophy.

Conclusions:

  • miRNA-1 and miRNA-133 play critical roles in regulating cardiac hypertrophy.
  • Modulating miRNA activity presents a potential therapeutic avenue for treating heart diseases.
  • Further research into miRNA function in cardiac physiology and pathology is warranted.