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Related Experiment Video

Updated: Jul 6, 2026

Intracranial Pharmacotherapy and Pain Assays in Rodents

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

Bromism caused by mix-formulated analgesic injectables.

P F Hsieh¹, Y T Tsan, D Z Hung

¹Department of Internal Medicine, Division of Neurology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China.

Human & Experimental Toxicology

|April 1, 2008

Summary

Chronic bromide intoxication (bromism) from pain injections is a newly identified risk. This study reports a case and highlights the continued use of bromide-containing injectables in Taiwan, urging clinical awareness.

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A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

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Published on: November 9, 2016

Area of Science:

Pharmacology
Clinical Toxicology

Background:

Bromism, a form of chronic bromide intoxication, is typically associated with various medications.
Injectable pain-relief medications have not been previously reported as a cause of bromism.

Observation:

A case of bromism in a 25-year-old female presenting with forgetfulness and gait instability after long-term use of injectable pain medication.
Analysis revealed severe hyperchloremia (171 mEq/L), a negative anion gap (-48.7 mEq/L), and elevated serum bromide levels (2150 mg/L).

Findings:

The patient recovered fully within 3 days following saline treatment.
Internet searches confirmed the availability of injectable medications containing significant amounts of sodium bromide (up to 1000 mg/ampoule) or calcium bromide (up to 800 mg/ampoule) in Taiwan.
Many analgesic/antipyretic and antihistamine injections containing bromides remain in use in Taiwan.

Implications:

Clinicians must be vigilant regarding the potential for iatrogenic bromism from injectable medications.
Increased awareness is crucial to prevent misdiagnoses and ensure patient safety.
This study underscores the need to re-evaluate the continued use of bromide-containing injectable formulations.