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Updated: Jul 6, 2026
08:23
Analyzing the Photo-oxidation of 2-propanol at Indoor Air Level Concentrations Using Field Asymmetric Ion Mobility Spectrometry
Published on: June 14, 2018
Poisoning with 1-propanol and 2-propanol.
M Vujasinovic1, M Kocar, K Kramer
1Department of Internal Medicine, Topolsica Hospital, Topolsica, Slovenia.
Human & Experimental Toxicology
|April 1, 2008
Summary
Simultaneous ingestion of 1-propanol and 2-propanol can alter their typical toxic effects. 1-Propanol slows 2-propanol metabolism, delaying ketosis and ketonuria in poisoning cases.
Area of Science:
- Toxicology
- Metabolic Biochemistry
Background:
- 1-Propanol and 2-propanol are isomeric alcohols with distinct metabolic pathways and clinical presentations in poisoning.
- 1-Propanol metabolism leads to propionic acid, causing metabolic acidosis and elevated anion gap.
- 2-Propanol metabolism yields acetone, resulting in rapid ketosis and ketonuria without acidosis.
Observation:
- A case of simultaneous lethal ingestion of 1-propanol and 2-propanol from hand disinfectant is presented.
- The patient experienced rapid loss of consciousness and respiratory arrest.
- Initial presentation included mixed acidosis with an elevated anion gap, but ketonuria was delayed.
Findings:
- Simultaneous poisoning with 1-propanol and 2-propanol alters their individual toxicological profiles.
- 1-Propanol significantly retards the metabolism of 2-propanol to acetone.
- Laboratory findings in mixed isomer poisoning are not simply additive and evolve over time.
Implications:
- Early diagnosis of mixed 1-propanol and 2-propanol poisoning requires consideration of delayed ketonuria.
- Understanding metabolic interactions is crucial for accurate clinical assessment and management of co-ingestions.
- This case highlights the importance of considering isomer-specific metabolism in toxicological emergencies.
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