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Presynaptically Silent Synapses Studied with Light Microscopy
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NMDA receptors inhibit synapse unsilencing during brain development

Hillel Adesnik1, Guangnan Li, Matthew J During

  • 1Departments of Cellular and Molecular Pharmacology, Physiology, and Neurology, University of California, San Francisco, CA 94143, USA.

Proceedings of the National Academy of Sciences of the United States of America
|April 1, 2008
PubMed
Summary

Deleting NMDA receptors surprisingly increases functional synapses in the brain. This challenges the idea that these receptors are essential for synapse development, suggesting a new model for neural circuit wiring.

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