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Updated: Jul 6, 2026
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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Nuclear receptors and inflammatory diseases.
1Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA. ywan@kumc.edu
Experimental Biology and Medicine (Maywood, N.J.)
|April 1, 2008
Summary
Nuclear receptors, including glucocorticoid and orphan receptors, are key regulators of inflammation. This review details their roles in various diseases and their underlying mechanisms.
Area of Science:
- Molecular Biology
- Endocrinology
- Immunology
Background:
- Glucocorticoids and their receptors are established regulators of inflammation.
- Inflammation is implicated in numerous diseases like atherosclerosis, obesity, diabetes, and neurodegenerative disorders.
- Emerging evidence highlights the role of orphan nuclear receptors in metabolic and inflammatory processes.
Purpose of the Study:
- To review the regulatory roles of nuclear receptors in the inflammatory process.
- To elucidate the mechanisms by which these receptors control inflammation.
- To highlight the involvement of nuclear receptors in various human diseases.
Main Methods:
- Literature review of studies on nuclear receptors and inflammation.
- Analysis of data from human and animal models.
- Synthesis of information on ligand-dependent and -independent regulation.
Main Results:
- Nuclear receptors, including glucocorticoid receptor and orphan receptors (e.g., PPARs, LXRs, FXR, NR4As, RXRs, PXR), modulate inflammatory responses.
- These receptors influence both inflammatory and metabolic profiles.
- Regulation occurs through ligand-dependent and -independent mechanisms.
Conclusions:
- Nuclear receptors are critical players in the inflammatory process.
- Understanding these roles offers insights into disease pathogenesis.
- Targeting nuclear receptors may provide therapeutic strategies for inflammatory diseases.
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