Related Experiment Video

Updated: Jul 6, 2026

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

Growth and bone mineralization in patients with juvenile idiopathic arthritis

Ozgur Okumus1, Muferet Erguven, Murat Deveci

  • 1Department of Pediatrics, Goztepe Training and Research Hospital, Istanbul, Turkey.

Indian Journal of Pediatrics
|April 1, 2008
PubMed

Insights

Children with juvenile idiopathic arthritis (JIA) experience growth and bone density issues. Early intervention is key to preventing long-term complications like osteoporosis and growth retardation.

Area of Science:

  • Pediatric Rheumatology
  • Pediatric Endocrinology
  • Pediatric Orthopedics

Background:

  • Juvenile idiopathic arthritis (JIA) can impact a child's growth and skeletal development.
  • Understanding the long-term effects of JIA on bone health is crucial for effective management.

Purpose of the Study:

  • To investigate the growth, development, and bone mineralization in children diagnosed with JIA.
  • To identify factors influencing growth and bone density in this pediatric population.

Main Methods:

  • Studied 30 children (4-17 years) with therapy-resistant JIA.
  • Assessed height, weight, puberty, bone mineral density (BMD), and serum markers (Ca, P, IGF-1).
  • Compared results with a control group of 30 healthy children.

Main Results:

  • JIA patients exhibited reduced height standard deviation scores (SDS) and growth retardation.
  • Lower BMD was observed in JIA patients compared to controls (p<0.05).
  • Younger age at disease onset correlated with lower BMD; steroids negatively affected growth; serum IGF-1 levels were significantly lower in JIA patients (p<0.0001).

Conclusions:

  • Early diagnosis and disease activity suppression are vital for preventing osteoporosis and growth retardation in JIA.
  • Annual BMD measurements are recommended for accurate osteoporosis diagnosis in JIA patients.
  • Vitamin D and calcium-rich nutrition, physical activity, and controlled steroid use may protect against bone loss.
Abstract

More Related Videos

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...