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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Rosai-Dorfman disease.

Madhumita Nandi¹, Rakesh Kumar Mondal, Supratim Datta

¹Department of Pediatric Medicine, Institute of Post-Graduate Medical Education and Research, (IPGMER), Kolkata, India. madhumitabanik@rediffmail.com

Indian Journal of Pediatrics

|April 1, 2008

Summary

Rosai-Dorfman disease, a rare condition, can manifest as cervical adenopathy or rare orbital involvement. Steroid treatment is crucial for managing severe symptoms like pressure, disfigurement, and fever.

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Area of Science:

Oncology
Pathology
Ophthalmology

Background:

Rosai-Dorfman disease (RDD) is a rare, benign proliferative disorder of unknown etiology.
It is characterized by the proliferation of histiocytes and plasma cells, often presenting with lymphadenopathy.

Observation:

This report details two cases of RDD.
Case 1 presented with typical cervical adenopathy.
Case 2 exhibited rare bilateral orbital involvement.

Findings:

Both patients required systemic corticosteroid therapy.
Treatment was necessitated by significant pressure symptoms, cosmetic disfigurement, and, in one case, recurrent high fevers.

Implications:

This highlights the diverse clinical presentations of RDD, including rare orbital manifestations.
Early diagnosis and prompt steroid treatment are vital for managing RDD complications and improving patient outcomes.
Further research into RDD pathogenesis and optimal therapeutic strategies is warranted.