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The Delphian lymph node in thyroid cancer.

Joseph D Isaacs¹, Catharina I Lundgren, Stan B Sidhu

¹University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St. Leonards, Sydney, NSW, Australia.

Annals of Surgery

|April 1, 2008

Summary

This summary is machine-generated.

Metastatic involvement of the Delphian lymph node (DLN) in thyroid cancer indicates advanced disease. DLN metastasis is an adverse prognostic marker, signaling the need for thorough assessment of central and lateral lymph node compartments.

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Area of Science:

Oncology
Endocrine Surgery
Head and Neck Cancer Research

Background:

The Delphian lymph node (DLN) is a potential indicator of thyroid malignancy and advanced disease.
Limited published data exist regarding the DLN's role in thyroid cancer.

Purpose of the Study:

To investigate the significance of Delphian lymph node (DLN) involvement in thyroid cancer.
To assess the DLN's predictive value for advanced thyroid cancer.

Main Methods:

Retrospective cohort study of 1000 patients undergoing total thyroidectomy.
Data sourced from the University of Sydney Endocrine Surgery database and histopathology records.
Analysis of DLN identification, metastasis, and correlation with clinicopathological features.

Main Results:

Delphian lymph node (DLN) metastasis was identified in 21.4% of thyroid cancer patients.
DLN involvement correlated with greater nodal disease, larger tumor size, and younger age.
DLN metastasis demonstrated high specificity for predicting further nodal disease in central (95%) and lateral (88%) compartments.

Conclusions:

Clinical appearance of the DLN is unreliable for detecting unsuspected thyroid cancer.
Metastatic DLN involvement is an adverse prognostic marker in papillary/medullary thyroid cancer.
DLN metastasis suggests advanced disease, necessitating comprehensive evaluation of neck lymph nodes.